The aim of this study is to evaluate the efficacy of cannabidiol versus a first-choice second-generation antipsychotic (risperidone) in patients with early psychosis and comorbid cannabis use. Cannabidiol, a constituent of the Cannabis sativa plant, has potential both as an antipsychotic and as a cannabis substituting agent. The prevalence of patients with psychosis and comorbid cannabis use (dual diagnosis) is rising with no approved specialized pharmacological treatment option. This is consistent with the time course of persisting neurocognitive impairment reported in recent studies.Ĭannabis use is an important risk factor for development of psychosis and further transition to schizophrenia. 11-Nor-9-carboxy-THC (THCCOOH) detection rates were 96.7% on admission, decreasing slowly to 95.7% and 85.7% on days 8 and 22, respectively 4 of 5 participants remained THCCOOH positive (0.6-2.7 μg/L) after 30 days, and 1 remained positive on discharge at 33 days.Ĭannabinoids can be detected in blood of chronic daily cannabis smokers during a month of sustained abstinence. Median 11-hydroxy-THC concentrations were 1.1 μg/L on admission, with no results ≥1.0 μg/L 24 h later. THC decreased gradually only 1 of 11 participants was negative at 26 days, 2 of 5 remained THC-positive (0.3 μg/L) for 30 days, and 5.0% of participants had THC ≥1.0 μg/L for 12 days. Of the 30 participants, 27 were THC-positive on admission, with a median (range) concentration of 1.4 μg/L (0.3-6.3). We quantified THC by 2-dimensional GC-MS. Samples were processed in an ice bath during sample preparation to minimize cannabinoid adsorption onto precipitant material. Thirty male chronic daily cannabis smokers resided on a secure research unit for up to 33 days, with daily blood collection. The persistence of Δ-tetrahydrocannabinol (THC) in chronic daily cannabis smokers' blood is unknown. Some 'per se' laws make it illegal to drive with any amount of drug in the body, while others establish blood, saliva, or urine concentrations above which it is illegal to drive. Cannabis is the illicit drug most frequently reported with impaired driving and motor vehicle accidents.

Wd drive utilities 1.4.0.5